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Dr Graham Desborough

Doctor, writer, mountaineer, photographer. Based in Auckland, New Zealand. My new book is 'How the Brain Thinks'.

Exercise and the Brain

There is more and more evidence about the benefits of exercise on the brain. In an article in the New York Times in October 2019, Gretchen Reynolds reviewed the evidence about the benefits of exercise, particularly in younger people.

‘Physically fit young adults have healthier white matter in their brains and better thinking skills than young people who are out of shape, according to a large-scale new study of the links between aerobic fitness and brain health. The findings suggest that even when people are youthful and presumably at the peak of their mental prowess, fitness — or the lack of it — may influence how well their brains and minds work.

We already have plenty of tantalizing evidence that aerobic fitness can beneficently shape our brains and cognition. In animal experiments, mice and rats that run on wheels or treadmills produce far more new neurons in their brains than sedentary animals and perform better on tests of rodent intelligence and memory. Similarly, studies involving people show strong relationships between being physically active or fit and having greater brain volume and stronger thinking abilities than people with low fitness or who rarely exercise.’

This week, again in the New York Times, she examined new evidence about how some of the benefits of exercise are produced at a cellular level

‘Many questions remain unanswered about how, at a cellular level, exercise remodels the brain and alters its function. Most researchers suspect that the process involves the release of a cascade of substances inside the brain and elsewhere in the body during and after exercise. These substances interact and ignite other biochemical reactions that ultimately change how the brain looks and works. But what the substances are, where they originate and how they meet and mingle has remained unclear.

So, for the new study, which was published this month in Science, researchers at the University of California, San Francisco, decided to look inside the minds and bloodstreams of mice. In past research from the same lab, the scientists had infused blood from young mice into older ones and seen improvements in the aging animals’ thinking. It was like “transferring a memory of youth through blood,” says Saul Villeda, a professor at U.C.S.F., who conducted the study with his colleagues Alana Horowitz, Xuelai Fan and others.’

No wonder then that billionaires are trying to obtain blood transfusions from younger people.

Me, I’d rather go for a run. See you out there.

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